Deep Brain Stimulation for Medication-Refractory Essential Tremor in a Musician Unable to Continue Performing
From a Silenced Guitar to a Return to the Stage: Bilateral VIM Thalamic DBS for Refractory Essential Tremor
PATIENT PROFILE
| Field | Details |
| Age | 52 years |
| Gender | Male |
| Occupation | Professional Classical Guitarist and Music Instructor |
| City | Bangalore |
| Presenting Complaint | Progressive bilateral hand tremor, worse during fine motor tasks and instrumental performance, over approximately eight years |
| Diagnosis | Essential Tremor: Bilateral, action-predominant, medication-refractory, confirmed on clinical assessment |
| Duration of Issue | Approximately eight years before surgical referral |
| Previous Treatments | Propranolol and primidone at maximum tolerated doses, a trial of topiramate, and Botox injections at another centre; no sustained functional improvement |
| Date of Procedure | May 2026 |
| Outcome | Excellent: sustained bilateral tremor control, return to professional performance |
THE PROBLEM
Condition
The patient, a professional classical guitarist, first noticed a fine tremor in both hands roughly eight years before presenting to Dr. Guruprasad Hosurkar, a Neurologist in Bangalore with a focused practice in tremor and Deep Brain Stimulation. The tremor was minimal at rest but became pronounced during sustained finger positioning and rapid string work, exactly the movements his performances depended on.
Over several years the tremor worsened. Bowing precision (in an earlier period of violin study) and later fretting-hand accuracy on the guitar both deteriorated. Handwriting became irregular, and pouring liquids or using cutlery in public became a source of visible embarrassment. He was treated sequentially with propranolol and primidone, and later a trial of topiramate, without meaningful benefit. Botox injections at another centre offered only brief, partial relief and mildly weakened grip strength, which further limited his playing.
By the time he was referred for a movement disorders opinion, the tremor had become disabling enough that he had stopped accepting performance engagements and had reduced his teaching load, relying on senior students to demonstrate difficult passages.
Emotional and Psychological Impact
Music had been the patient’s primary professional identity for over three decades, and the gradual loss of fine control eroded both his income and his sense of self. He described increasing anxiety before any task requiring precise hand movement, and a growing reluctance to be seen playing in front of colleagues or students. The initial consultation addressed this directly: clarifying that his tremor was a well-characterised, treatable neurological condition rather than a sign of general decline, and setting a realistic expectation that surgery could restore, not just stabilise, his functional hand control.
CONSULTATION & TREATMENT PLAN
What Was Assessed
- Detailed tremor history: onset, laterality, task-specificity, and progression over eight years
- Motor examination distinguishing action, postural, and kinetic tremor from resting tremor
- Fahn-Tolosa-Marin (FTM) Tremor Rating Scale scoring, including Archimedes spiral drawing and handwriting samples
- Video documentation of tremor during simulated fine motor and playing-position tasks
- Review of prior medication trials, doses, duration, and tolerability
- MoCA cognitive screening and mood assessment
- Stereotactic MRI brain to exclude structural lesions and plan surgical targeting
- Blood panel: CBC, thyroid, renal, liver, metabolic screen
- Multidisciplinary review with neurosurgery for DBS candidacy
Why This Approach Was Chosen
The tremor was bilateral, action-predominant, and worsened with sustained fine motor use, a pattern consistent with essential tremor rather than a resting, Parkinsonian tremor. He had already failed adequate trials of first-line and second-line medications, and the tremor caused clear, significant functional disability in a task that depended entirely on manual precision. This combination, disabling tremor, refractory to pharmacological therapy, and suitability for stereotactic neurosurgery, met accepted criteria for Deep Brain Stimulation targeted at the ventral intermediate nucleus (VIM) of the thalamus. Occupational therapy for fine motor and instrument-specific retraining was planned from the outset, since medication and stimulation reduce tremor but relearning precise, performance-level control also requires structured practice.
“In musicians and other precision-dependent professionals, essential tremor is often dismissed early as nerves or fatigue, and by the time it is correctly identified, the functional loss is already significant. Once a tremor is confirmed as action-predominant and refractory to adequate medication trials, VIM thalamic DBS is one of the most reliable ways we have to give that fine control back.” — Dr. Guruprasad Hosurkar.
BASELINE CLINICAL ASSESSMENT
Baseline Fahn-Tolosa-Marin Tremor Rating Scale total score: 54 (severe). Action and postural tremor graded 3/4 in the right hand and 3/4 in the left hand, with mild kinetic overshoot on finger-to-nose testing. No resting tremor, rigidity, or bradykinesia was noted, and gait and postural reflexes were normal, arguing against a Parkinsonian process. Archimedes spiral drawings were markedly distorted bilaterally, and handwriting showed pronounced irregularity. Mild voice tremor was present but not functionally limiting. MoCA score was within normal range.
Stereotactic MRI brain showed no structural abnormality and confirmed suitable anatomy for bilateral VIM targeting.
TREATMENT DETAILS
Step-by-Step Overview
- Stereotactic MRI-based surgical planning targeting the bilateral VIM nucleus of the thalamus
- Awake bilateral electrode implantation with microelectrode recording and intraoperative test stimulation to confirm tremor suppression and check for side effects
- Subclavicular implantation of a rechargeable implantable pulse generator (IPG), connected to the electrodes via subcutaneous extension leads
- Device activation at approximately two weeks post-surgery, once incisions had settled
- Weekly programming sessions for the first month, tapering to monthly review, adjusting amplitude, frequency, and pulse width to balance tremor control against speech and balance side effects
- Occupational therapy: instrument-specific fine motor retraining, grip and dexterity drills, graded return to practice sessions
- FTM Tremor Rating Scale reassessment at 6 weeks, 3 months, and 6 months
Treatment Facts
| Field | Details |
| Duration | Ongoing: staged programming over 6 months with long-term follow-up |
| Setting | KIMS Hospital, Mahadevapura, Bangalore: inpatient surgery, outpatient programming |
| Procedure | Bilateral VIM Thalamic Deep Brain Stimulation |
| Device | Rechargeable subclavicular implantable pulse generator with bilateral thalamic leads |
| Allied Therapies | Occupational Therapy (instrument-specific retraining), Physiotherapy |
| Complications | None |
| Inpatient Admission | Yes: surgical admission of approximately 3 days |
POST-TREATMENT RESULTS
Intraoperative test stimulation already showed near-complete suppression of the action tremor in both hands. After device activation at two weeks, formal programming began, and tremor control improved steadily over the following month. By six weeks, the FTM Tremor Rating Scale score had improved from 54 to 19, a reduction of roughly 65%. Archimedes spiral drawings and handwriting samples showed marked improvement.
At three months, both leads were optimised and the patient had resumed daily practice sessions. Occupational therapy focused on rebuilding the fine motor sequences specific to fretting-hand technique. By six months, he had returned to teaching a full studio load and had accepted his first small performance engagement since symptom onset.
Outcomes at a Glance
| Field | Details |
| Tremor Recovery | ✔ FTM score: 54 to 19 at 6 weeks; continued improvement at 6 months |
| Functional Independence | ✔ Returned to full teaching load and public performance |
| Fine Motor Control | ✔ Occupational therapy produced measurable gains in instrument-specific dexterity |
| Patient Satisfaction | ✔ Described regaining confidence in both playing and everyday tasks |
| Complications | ✔ None |
| Medication Burden | ✔ Reduced reliance on propranolol and primidone post-DBS |
PATIENT FEEDBACK
“For years I quietly worked around my tremor, changing fingerings, avoiding certain pieces, and eventually turning down concerts. I had tried the tablets and they simply were not enough. Dr. Guruprasad Hosurkar was the first person to explain clearly why the medication was not going to be sufficient and what surgery could realistically do. The change after programming was extraordinary. I am teaching again, and I played my first public piece in years last month.”
- Profile: Male · 52 years · Professional Guitarist · Bangalore
- Condition: Medication-refractory Essential Tremor, symptomatic for approximately eight years
- Neurologist:Dr. Guruprasad Hosurkar | KIMS Hospital, Mahadevapura, Bangalore | May 2026
POST TREATMENT CARE & RECOVERY
Instructions Given to Patient
- Continue scheduled programming visits to fine-tune amplitude and pulse settings as tremor patterns stabilise
- Occupational therapy twice weekly with a structured home practice routine
- Gradual, graded return to performance engagements rather than an immediate full schedule
- Monitor and report any speech changes, balance issues, or paraesthesia after programming adjustments
- Routine IPG battery checks and awareness of MRI-conditional device precautions
- Continue low-dose propranolol only if required for residual breakthrough tremor
- Follow-up FTM Tremor Rating Scale reassessment at 12 months
Recovery Timeline
| Field | Details |
| Week 1–2 | Surgical recovery; device implanted but not yet activated |
| Week 2–4 | Device activated; initial programming begins; early tremor suppression noted |
| Week 6 | Programming optimised; 65% improvement in FTM score confirmed |
| Month 2–3 | Occupational therapy established; daily practice resumed |
| Month 3–6 | Continued gains in dexterity and endurance; return to teaching and first performance |
FAQs
1. Can essential tremor stop someone from working or performing music?
Yes. When essential tremor is action-predominant and affects fine motor control in both hands, it can make precise tasks such as playing an instrument, writing, or using tools very difficult, even when the tremor looks mild at rest.
2. What does medication-refractory essential tremor mean?
It means the tremor no longer responds adequately to first-line medications such as propranolol and primidone, even at maximum tolerated doses, or the side effects outweigh the benefit.
3. How does deep brain stimulation help essential tremor?
DBS delivers continuous, adjustable electrical stimulation to the ventral intermediate nucleus of the thalamus, interrupting the abnormal signals that generate tremor. It does not destroy brain tissue and can be adjusted or reversed.
4. Can a musician return to performing after DBS for essential tremor?
Many patients regain enough fine motor control for detailed manual tasks, including playing an instrument, though the degree of recovery depends on tremor severity, disease duration, and post-operative programming and therapy.
5. Is deep brain stimulation surgery reversible?
Yes. Unlike lesioning procedures, DBS does not destroy brain tissue. Stimulation can be adjusted, paused, or the device switched off, which preserves future treatment options.
Disclaimer: This case study is for educational purposes only. Patient identity has been withheld per confidentiality guidelines. For a related recovery story, see our Parkinson’s Disease case study, or browse more patient stories on our Case Study and Blog pages.
